Population trends show distinct patterns. An increase occurred from 2010 to 2011, followed by a decline until 2014, when the population reached 3,925. Subsequent years saw another decline, stabilization, and recent increase. These fluctuations may relate to changes in housing availability, economic conditions, or urban development initiatives.

The neighborhood's proximity to the Genesee River and the University of Rochester is notable. This location potentially influences the demographic composition, attracting students, university staff, and long-term residents. The riverside location may provide recreational opportunities and green spaces.

Based on the national average household size, an estimated 1,435 housing units existed for the 2022 population. This suggests a diverse housing stock accommodating various household types.

Plymouth-Exchange presents as a dynamic urban neighborhood with a relatively stable but fluctuating population. The high density indicates an urban lifestyle with city conveniences. The location near educational institutions and natural features likely contributes to its appeal and diverse demographics.